Why does chicken always taste bad on pizza?

Thanks for the A2A!

Chicken doesn't automatically taste bad on pizza.

Tomato sauce tastes pretty bad with stringy grilled chicken, especially if the meat is dark meat. In my opinion this is just because the textures and smells clash, not because of pizza or chicken itself.

You could probably get the same effect from pork meat too, if you really wanted to.

Chicken tastes better where the sauce is pesto or white sauce or nonexistent (basically a flatbread).

What is nadi shodhan pranayam?

The word nadi means 'channel' or 'flow' of energy and shodhana means 'purification'. Nadi shodhana, therefore, means that practice which purifies the nadis.

It is also called Anulom – vilome Pranayama as both of the nostrils are used alternatively.

The technique:

Stage: 1

The thumb is above the right nostril and the ring finger above the left. These two fingers control the flow of breath in the nostrils by alternately pressing on one nostril, blocking the flow of breath, and then the other.

Close the right nostril with the thumb.

Inhale and exhale through the left nostril 5 times.

The rate of inhalation/exhalation should be normal.

Be aware of each breath.

After completing 5 breaths, release the pressure of the thumb on the right nostril and press the left nostril with the ring finger, blocking the flow of air.

Inhale and exhale through the right nostril 5 times, keeping the respiration rate normal.

Lower the hand and breathe 5 times through both nostrils together.

This is one round. Practise 5 rounds or for 3 to 5 minutes, making sure that there is no sound as the air passes through the nostrils.

Practise until this stage is mastered before commencing the next stage.

Stage: 2

After practicing the stage 1 for one week, start inhaling and exhaling alternatively. Press the right nostril with the thumb and inhale with the left. After full inhalation close the left nostril and release the thumb’s pressure from the right nostril and exhale completely. As soon as you complete the exhalation, start inhaling with the same nostril i.e. the right nostril and after full inhalation close the right nostril and release the left nostril to completely exhale. This is one cycle. Do 10 cycles. Add every week 5 more cycles.

Keep the duration of inhalation and exhalation equal.

Stage 3:

After 4 or 5 weeks increase the duration of inhalation and exhalation. Suppose you Inhale up to the counting of 5 then exhale also up to the counting of 5. Increase the inhalation and exhalation by 1 every day. Go up to the counting of 10.

Stage:4

Practice in the same way for 4 to 5 weeks. After that in the same fashion you can double the duration of exhalation by double of the duration of the inhalation. In that case you can start the inhalation with up to the counting of 5 and exhalation with up to the counting of 10. Add every day 1 to inhalation and 2 to exhalation. Do this way up to the counting of 10 for the inhalation and 20 for the exhalation. Practice the same way for 4 to 5 weeks.

Stage: 5

After that you can practice with kumbhaka i. e. retention of the breath. When you inhale retain the breath for 1 second and keep it increasing up to the comfortable level.

Note: Stages 3, 4 and 5 should be practiced under the guidance of an experienced yoga teacher.

Why is the uterus lining thick?

The thickness of the uterine lining changes throughout the menstrual cycle. It is thinnest at the end of the period, and it is thickest at midcycle. The fertilized egg can work itself the lining and gain nutrition from the lining.

Hope this helps.

How do antibiotic resistant bacteria resist antibiotics?

Antibiotic resistance is caused by several mechanisms that could be either intrinsic i.e. changes in antibiotic target or acquired i.e by acquiring genes for resistance from other bacteria. Second mechanism is more dangerous as it makes bacteria resistant to antibiotics that could be shared among other bacteria. New resistance mechanisms are constantly being discovered, and new genes and vectors of transmission are identified on a regular basis.

There are many research article and updated reviews showing recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

Here are some of the common mechanisms that bacteria use to make antibiotic ineffective for them. For details refer this review. http://www.nature.com/nrmicro/jo…

  1. Prevention of access to target

Reduced permeability-Reducing the permeability of the outer membrane and limiting antibiotic entry into the bacterial cell is achieved by the downregulation of porins or by the replacement of porins with more-selective channels.

Increased efflux. When overexpressed, efflux pumps can also confer high levels of resistance to previously clinically useful antibiotics. Some efflux pumps have narrow substrate specificity (for example, the Tet pumps), but many transport a wide range of structurally dissimilar substrates and are known as multidrug resistance (MDR) efflux pumps.

  1. Changes in antibiotic targets by mutation – Mutation in genes that encode target protein where a particular antibiotics binds leads to resistance for that particular antibiotic. like
  2. Modification and prevention of targets – It does not require any genetic mutation for preventing target from antibiotics but it makes some chemical changes or modifications (epigenetic modifications) like methylation at drug-binding site of the protein. e.g erm gene family methylates 16s rRNA so that antibiotics like macrolides, lincosamines and streptogramins can not bind to it. Another example is the qnr genes that encode pentapeptide repeat proteins (PRPs), which bind to and protect topoisomerase IV and DNA gyrase from the lethal action of quinolones
  3. Direct modification of antibiotics

Inactivation of antibiotics by hydrolysis. B-lactamase enzymes are best examples for this type of resistance development as they degrade the antibiotic so it is no longer available to kill bacteria. Thousands of enzymes have since been identified that can degrade and modify antibiotics of different classes, including β-lactams, aminoglycosides, phenicols and macrolides.

Inactivation of antibiotic by transfer of a chemical group. The addition of chemical groups to vulnerable sites on the antibiotic molecule by bacterial enzymes also causes antibiotic resistance. It is accomplished by preventing the antibiotic from binding to its target protein as a result of steric hindrance. Acyl, phosphate, nucleotidyl and ribitoyl groups are the groups that are mostly involved in this type of resistance. e.g. aminoglycoside-modifying enzymes: acetyltransferases, phosphotransferases and nucleotidyltransferases.

What diseases affect the circulatory system?

Issues of the system itself

  • Coronary heart disease – coronary arteries giving blood to the heart get clogged
  • Atherosclerosis – hardening and constriction of arteries
  • Heart valve issues
  • Congestive heart failure – heart getting too weak
  • Hypertension(high blood pressure)
  • Anemias (thalassemia, sickle cell, iron deficiency, pernicious, and possibly others) – red blood cells can't deliver enough oxygen for some reason
  • Congenital heart or vascular defects

Issues of other things that affect it

  • Diabetes – the high blood sugar damages tiny blood vessels of the micro-circulation
  • Kidney failure – the inability to filter blood properly can mean increases in blood pressure. Toxin buildup can also lead to damaging blood vessels
  • Probably forgetting a few

When you overclock what are you actually overclocking, the CPU or the GPU?

Well, you’ll know what you’re overclocking depending on what your intentions are, and where you are doing the overclocking.

Generally, CPU overclocking is done within the UEFI BIOS, by adjusting voltages for power delivery, clock speeds to increase performance, among other options. However, it requires your CPU is “unlocked” for you to be able to overclock effectively (“unlocked” in this case referring to the CPU having an unlocked clock multiplier), otherwise the closest you can do is base clock overclocking, which is far less unstable, as it affects everything in your system; not just the speed of your CPU, but also how PCIe expansion cards work, which result in substantial instability.
With that being said, there exists software-based overclocking utilities for CPUs, such as AMD OverDrive for AMD processors, but again, they require an unlocked processor to do anything meaningful.

On the other side, GPU overclocking is almost entirely done through software, such as EVGA PrecisionX, MSI Afterburner, ASUS GPU Tweak and so on; each vendor usually has an overclocking utility to go with their graphics processor, but it is worth noting that there’s usually no limit regarding which program you use, so long as that vendor also does the specific brand of GPU; you wouldn’t overclock an AMD Radeon RX580 using EVGA PrecisionX since EVGA do not do AMD GPUs.
These are used, of course, to increase clock rates of not just the processor itself, but also the VRAM used in the card, allowing it to stream data quicker, as well as altering core voltage to allow for these overclocks to work.

It’s also worth noting that, as complicated as it looks, it’s not really THAT complicated – it’s just a case of knowing that it’s not just as easy as flipping a switch. There is a lot of work in each case that you have to do and dedicate yourself to if you want noticeable results, and ensuring the computer is rocksteady and stable, instead of bluescreening everytime you try to do something and popping up a clock watchdog error.

When did you first discover that you're an INFP?

I found out in college (2012).

Of course, I think I knew for some time what this bundle of traits were I just didn’t know how to tie them up with a pretty bow yet.

My professor called us all over into separate sections based on our MBTI, and I ended up with about ten women, and one other guy. She went over each of the traits and cognitive functions and asked us if they applied to us –

Which for me (and everyone else in my group) they did.

Was some of it extrapolation? Projecting those traits onto myself and pulling something that was 75% me into the 100%? Maybe.

But, better to have 75% clarity on a shared function with someone else than have 0%, which is what I had before I was able to worm my way into MBTI.

MBTI didn’t give me all the answers to life, but it gave me the tools to ask some very substantive and intriguing questions about myself. It allowed me to speak from a point of reference, a language with which to communicate my heart.

Often when I answer on here, it isn’t from some professional expertise, it is just from my own life expertise – and I find myself shocked at how many people in the MBTI type think or feel similarly or exactly the same.

It’s uncanny.

Because I just let things flow freely from my heart, and if they resonate they resonate and if they don’t then I live with the results.

MBTI gives us another thread to tie ourselves together with – it gives people, especially those with introverted tendencies (okay, hermetic, ascetic tendencies) like me the ability to reach out and be heard, and also to hear.

And I love being able to compare my type to someone else’s (though I really only know about my own type very well…because, well…I’m embarassed to say but I really like how other INFP act and carry themselves. It’s so creative, heartfelt and magical. So I’m a bit biased, haha~) and just get something I don’t get normally – which is a good starting point for interaction.

It’s not exactly like INFP’s form groups often….

It’s just a human thing – I love knowing there is someone else just like me, or similar or at least…somewhat.

It helps me check my sanity!

Anyways, MBTI isn’t some golden treasure trove in my opinion, and sometimes it isn’t 100% on the spot. But it gives you a starting point, at least a map, at least a person at the gas station going “turn left”, you know?

We’re all reaching and grasping for answers, and MBTI helps us look inside ourselves and see some reflections. It’s up to us to ensure that we properly and truthfully use them to express and emote ourselves so we meet people who have genuine things in common with us, and know how to best deal with those who contrast us.

Anyways I kept you here too long, so I hope that gives you some idea when I learned and how I think about it! And answers your question!

Cheers,

J

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